ESTIMATION OF LIPID PROFILE AND GLYCEMIC STATUS AND LIVER ENZYMES, AMONG PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Abstract

Aim: The aim of the study is mainly to evaluate the association of obesity, liver enzymes, lipid profile and glycemic status with Non -alcoholic Fatty Liver Disease (NAFLD). Methods: This cross-sectional observational study Results: This study shows that characteristics of studied population (n = 400) as control, The study population was categorized into three age groups viz. 18-35 yrs, 36-60 yrs and >60 yrs. Out of the 400 subjects studied more than 50% belonged to the age group 36-60 years, 27.5% to the age group18-35 years and the remainder to the group above 60 years. The genders wise distribution of study group is presented 53% of the subjects were females and 47% subjects were males. 59.5% of the subjects were obese according to the WHOs classification of BMI for Asians. 18.5% were overweight and the remaining 22% were normal. 25% of the subjects were diabetics and 20 % were hypertensives. The association between the prevalence of NAFLD and the age categories mentioned previously, gender, BMI & comorbidities was tested using Chi-Square test. There was a significant association with age, BMI, DM and HTN with a P-value of 0.003, 0.0.000, 0.000 and 0.000 respectively. No significant association was found with gender. The results of Chi-square tests performed to find out the association between NAFLD & serum levels of liver enzymes. There was no significant association between NAFLD and liver enzymes. The results of the Chi-square tests performed to find out the association between NAFLD & serum lipid levels. A significant association was found between the prevalence of NAFLD and total cholesterol, triglycerides, LDL-C and VLDL-C. No significant association was observed between NAFLD and HDL-C. The association between NAFLD and the glycemic status was tested. There was a significant association between plasma fasting glucose level and NAFLD. The percentage of subjects diagnosed with NAFLD in each of the various stages according to their Fibroscan results. Among the 75 NAFLD patients, 80 % of patients were in fatty liver stage, 17,3% had had progressed to NASH and 2.7% progressed to the fibrosis stage. None of the patients were found to have liver cirrhosis. There was a significant association between the HBA1c and the progression of NAFLD with a P-value of 0.001. A significant association was found to exist between the various stages of NAFLD and the plasma fasting glucose level. The P-value was 0.025. The results are summarized in different tables. Conclusion: The Prevalence of NAFLD in the study population was 18.8%.The prevalence of NAFLD was higher among males. Age, BMI and co-morbidities like diabetes and hypertension were significantly associated with NAFLD. A significant association between NAFLD and total cholesterol, triglycerides, LDL-C, VLDL-C & fasting glucose was observed. There was a significant association between disease progression and glucose intolerance.