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Abstract
Purpose: Rats are widely used to study tissue mechano-adaptation in the context of knee homeostasis and degeneration. In particular, surgical interventions are often used in rats to destabilize the knee, and to induce osteoarthritis. To characterize local mechanical stimuli in knee tissues and examine their mechano-adaptive response, loading (i.e. contact forces) must be estimated at the joint level. The purpose of this study is to estimate knee contact forces in the knee of intact rats using musculoskeletal modeling.
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