Abstract
Differential pulse anodic stripping voltammetry (DPASV) was applied for the simultaneous determination of zinc and copper in multivitamin tablet (supradyn and centrum). Determination of the metals was made in ammonium acetate buffer (pH 4.5) with a scan rate of 0.01 V/s by Hanging Mercury Dropping Electrode (HMDE).The solution was stirred during electrolysis at -1.3 V for 300 s in the potential range of -1.3 to + 0.1 V. Concentrations of zinc and copper in supradyn drug sample were found to be 1.80 and 2.9 mg/tablet and for centrum drug sample were found to be 4.6 and 0.94 mg/tablet respectively.
Highlights
Multivitamin tablets are very popular and widely used in our country and abroad
The present paper describes electrochemical characterization of some commercially available multi vitamin tablets for trace metals like Zn and Cu using differential pulse stripping voltammetry
The outer coatings of the multivitamin tablets, considered for the study was removed by washing it with deionised water and it was dried in oven at 120 0C for one hour
Summary
Multivitamin tablets are very popular and widely used in our country and abroad They contain, in general, essential vitamins (C and E) and some other trace elements. Electrochemical stripping analysis has long been recognized as a powerful technique for detection of traces of heavy metals in drug samples[14]. The present paper describes electrochemical characterization of some commercially available multi vitamin tablets for trace metals like Zn and Cu using differential pulse stripping voltammetry. Standard solutions of Cu and Zn were prepared by appropriate dilution of stock solution with deionized water. Stock solutions of Cu & Zn (500 ppm) were prepared with individual pure nitrates by diluting with deionised water. The outer coatings of the multivitamin tablets, considered for the study was removed by washing it with deionised water and it was dried in oven at 120 0C for one hour. The solution was cooled and filtered with Whatman paper no. 42 and diluted up to 100 mL with deionised water
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