Estimation of flavonoids and tannins extracted from medicinal plants on gentamicin-induced nephrotoxicity in local Iraqi rabbits

Abstract

The present study aimed to find out the effect The study aimed to extract flavonoids and tannin from sumac, myrtle, and on domestic rabbits exposed to nephrotoxicity with gentamicin. the percentage of flavonoids recorded from myrtle and Sumac is 13.8%, and 12.7%, respectively. The percentage of tannin recorded from myrtle and Sumac is 15.9 %, and 12.7%, respectively. The study was conducted inside the body of the organism and nephrotoxicity was developed with gentamicin by injecting animals 80 mg/ml/day (IP) for two weeks, after which I was dosed orally with the Flavonoid extract of sumac and myrtle and tannin extract of sumac and myrtle for a month at a rate of 1 ml/kg/day. A significant increase in the group’s dose was found with gentamicin. An increase of 0.05 compared to the healthy control group. As well as a significant decrease of 0.05 for the groups treated with extracts compared to the control group for urea and creatinine. The total protein showed a significant increase of 0.05 for the group administered with gentamicin compared with the healthy control group and a significant decrease for the groups fed with extracts compared to the control group treated with gentamicin. As for albumin, a significant decrease was recorded for the group treated with gentamicin compared to the healthy control group by 0.05, and a significant increase for the groups treated with plant extracts compared with the control group treated with gentamicin. Uric acid showed a significant decrease in the groups treated with gentamicin compared with the healthy control group.