Estimation of extraction efficiency of salidroside from Rhodiola rosea using deep eutectic solvents

Abstract

This article is devoted to the new possibilities of extraction of biologically active substances (BAS) from Rhodiola rosea L. This plant contains such BAS as salidroside, rhodiosin, rosavin, rosarin, rosin, which are glycosides of cinnamon alcohol and tyrosol. Pharmacological effects Rhodiola rosea include adaptogenic and stress- protective, cardioprotective, antioxidant effect, stimulating the central nervous system, anti-fatigue, antidepressive, anxiolytic, endocrine activity normalizing and life-span increasing effects. One of the promising methods for extracting biologically active substances is extraction using deep eutectic solvents. The aim of this work is to assess the applicability of three deep eutectic solvents for the extraction of biologically active substances, in particular, salidroside, from Rhodiola rosea. In this work the maceration method is used to obtain extracts and the HPLC method is used for the semi-quantitative analysis of the salidroside content. It has been established that the most suitable extractant for salidroside extraction is a mixture of choline chloride + malonic acid + methanol. Extractants containing choline chloride and urea, in contrast, do not extract salidroside from Rhodiola rosea.