Abstract
Extracorporeal membrane oxygenation (ECMO) is a treatment that supports heart and lung functions with a circulation circuit external to the body. In ECMO, it is important to monitor blood oxygen saturation (SO 2 ) in the circulation tube. As a means of continuous SO 2 measuring, a special connector is inserted into the circuit. However, this method is unsuitable for emergency treatment. Therefore, it is necessary to measure blood SO 2 in the tube without the connector. However, this creates problems for SO 2 estimation, due to varying blood concentration and flow velocity, hemolysis, and wall thickness of the tube. Therefore, we developed a SO 2 estimation method that can calibrate the variation in blood concentration. The method is based on a conversion model between absorbance and SO 2 (CAS), which varies depending on the concentration. In this method, the CAS for the SO 2 estimation is estimated by CAS corresponding to two blood samples prepared in advance with different concentrations. The experiment for SO 2 estimation was conducted with a spectroscope, a halogen light source, and a cut tube. We confirmed that the average error of estimated SO 2 against the SO 2 values measured by a gas analysis was 3.8% within a blood volume concentration range from 50 to 90%. In future work, to improve the estimation accuracy, we will improve our method by investigating other factors that may affect the accuracy.
Highlights
An Extracorporeal membrane oxygenation (ECMO) system mainly consists of circulation tubes, an artificial pump, and an artificial lung external to the body
To evaluate our method, blood absorbance was measured under conditions with various blood concentrations and SO2 values
After we obtained two functions between absorbance and SO2, which were defined as CASP, we obtained CASE to estimate the blood SO2 in the ECMO tube by employing CASPs for blood volume concentrations (VCs) calibration
Summary
A. EXTRACORPOREAL MEMBRANE OXYGENATION Extracorporeal membrane oxygenation (ECMO) has been employed for patients who need support for heart and lung function (e.g., heart failure or lung transplant) since 1971 [1]. An ECMO system mainly consists of circulation tubes, an artificial pump, and an artificial lung external to the body. In this system, venous blood is extracorporeally withdrawn from a patient through a catheter placed in the vena cava and blood flow is generated by the centrifugal pump. After the blood is oxygenated and decarboxylated by the artificial lung, it is returned to the patient. When the blood flows though the artificial lung, the O2 and CO2 of the blood by
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