Estimation of biogenic amines and biothiols by metal complex of fluorescent organic nanoparticles acting as single receptor multi-analyte sensor in aqueous medium

Abstract

A novel chemosensor based on metal complex of fluorescent organic nanoparticles (FONs) of new receptor (1) with ferric ions has been developed through simple synthetic procedure. The prepared receptor and its complex with ferric ions were subjected to FONs using re-precipitation method. FONs (N1) and FONs-Fe3+ ensemble (N1.Fe3+) were characterized using various techniques such as NMR, EDAX and DLS. The N1.Fe3+ were further investigated for their sensor properties and found them selective for determination of tyramine and 4,6-diamino-2-mercaptopyrimidine, having no interference from any other biogenic amines or biothiols. N1.Fe3+ showed a detection limit as low as 4.95nM and 3.02nM respectively for tyramine and 4,6-diamino-2-mercaptopyrimidine, fulfilling the concept of “Single receptor multianalyte determination”.