Abstract
Average acoustic concentration (AAC) is one important parameter of quantitative ultrasonic assessment of soft tissues. The objective of this study is to examine the AAC of Chinese hamster ovary (CHO) cells at varied cell densities using ultrasonic backscatter. The CHO cells were evenly distributed in 2% agar and the densities ranged from 500,000 to 54,000,000 cells/mL. Measurements of backscattered ultrasound were obtained over the frequency range of 17 to 80 MHz. Estimates of Average Scatterer Diameters and AAC were made by comparing the backscattered power spectra with three scattering models: Fluid‐filled Sphere model (FFSM), Spherical Gaussian model (SGM), and Concentric Sphere Model (CSM). Over the frequency range of 28 to 50 MHz, the estimated ASDs were 20.0±0 μm with FFSM, 22.2±6.0 μm with SGM, and 20.1±6.1 μm with CSM. In the cell density range of 500,000 to 10,000,000 cells/mL, the estimated AACs increased almost linearly from 10 to 34 dB/mm3 using FFSM, from 16 to 39 dB/mm3 using SGM, and from 8...
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