Abstract
The use of reversed-phase liquid chromatographic retention parameters in a modified Hildebrand-Scott equation to describe the aqueous solubilities of non-electrolyte liquids and solids has been studied. The results indicate that, for 32 model solutes of various characters, a semiempirical relationship between aqueous solubility, a theoretical capacity factor obtained by extrapolation of retention data in simple binary systems to a pure aqueous eluent and a function of solute melting points and entropies of fusion can be used to give good estimates of aqueous solubilities. Relationships are given between extrapolated capacity factors and liquid-liquid distribution coefficients or smoothed surface areas. It is suggested that the assumptions and intricacies often needed to calculate the last two parameters make the chromatographic parameter an appropriate candidate for describing solute non-ideality and for use in the modified Hildebrand-Scott equation.
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