Estimation of Anxiolytic Efficacy of Carica Papaya L. Seeds using Experimental Animal Models of Anxiety

Abstract

Background: Natural remedies have garnered global recognition for their therapeutic applications, supported by their unique nutritional and bioactive compositions. Among these, Carica papaya L., commonly known as papaya, has been historically valued not only for its nutritional benefits but also for its medicinal properties. The diverse chemical compositions of its leaves, seeds, and fruit contribute to their varied therapeutic uses. Objective: This study aims to investigate the anxiolytic effects of aqueous extracts from Carica papaya L. seeds using various experimental animal models of anxiety. Methods: Aqueous extracts of Carica papaya L. seeds were administered to Albino mice in a controlled laboratory setting. The anxiolytic effects were evaluated using four experimental models: the open field test, head dip test, cage crossing, and stationary rod test. Results: The administration of papaya seed extract resulted in a statistically significant reduction in peripheral square crossings by 40% and cage crossings by 50% in the open field and cage crossing tests, respectively. The head dip test saw a decrease in head pokes by 45%, and the time to cross the stationary rod was reduced by 30% compared to controls. Conclusion: The findings indicate that Carica papaya L. seeds possess pronounced anxiolytic properties, suggesting their potential utility as a natural adjunct therapy in managing anxiety disorders.