Abstract
Extended Hildebrand solubility approach (EHSA) was applied to estimate and correlate the solubilities of itraconazole in 1,4-butanediol + water mixtures at 298.15 K. Experimental solubilities and properties like entropy of fusion and ideal mole fraction solubilities were determined. EHSA was applied to estimate interaction parameter ′W′ to understand the solute solvent interaction. Theoretical solubilities were calculated by using ′W′ as a function of solubility parameter of solvent blend (δ1) and by direct method using logarithmic experimental solubilities (logX2) against solubility parameter of solvent mixture (δ1). Prediction capacities of EHSA and direct method were compared using mean percent deviations obtained while comparing theoretical solubilities with experimental ones. Itraconazole solubility was increased in all the proportions of solvent mixtures and was found to be highest at 0.9 mass fraction of 1,4-butanediol where solubility parameter of drug matched with solvent mixture. Prediction capacity of EHSA was found to be better with regular polynomial equation of order 5 with mean deviation of − 1.69%. Using EHSA, the solubility of any solute can be adequately predicted with the knowledge of few physicochemical properties.
Published Version
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