Estimation and Assessment of Plasma D-Dimer Levels in HIV Patients

Wafa Hamid Haroun Himmat,Nasr Eldeen Ali Mohammed Gaufri

doi:10.4236/jbm.2016.410001

Abstract

Background: The elevation of plasma D-dimer levels is fully described and associated with the increase of the mortality of patients with HIV. The present study was aimed to estimate and assess the plasma D-dimer levels in HIV patient. Material and Methods: A case control study done in May 2015. A total of 100 subjects were enrolled in this study; 50 were patients professionally diagnosed by HIV; 25 (50%) were males and 25 (50%) were females; their mean age is 35 years. Further 50 normal healthy individuals as normal control group: their gender and age were matched with patient groups. The platelets poor plasma (PPP) was immediately prepared from citrated blood, then the plasma D-dimer level was measured using (MISPA-i2 Reagent) Switzerland. Data were analyzed using statistical packing for social sciences program (SPSS) 20. Results: The D-dimer levels was significantly higher in patient with HIV compared with the normal healthy control group (Mean and STD 502.2 ± 287.8 vs 251.8 ± 152.7 P. value 0.01). Conclusion: The D-dimer level was significantly higher in patient with HIV compared with those in normal healthy control group.

Highlights

HIV is lentivirus that causes HIV infection and acquires immunodeficiency syndrome (AIDS) [1] [2]
AIDS is a condition in humans in which progressive failure of the immune system allows life-threating opportunistic infections and cancers to thrive without treatment average survival time after infection with HIV is estimated to be 9 to 11 years depending on the HIV subtype [3]
The present study showed that the D-dimer level was significant increased in patient with HIV when compared with the normal healthy control group (Mean and STD were 502.2 ± 287.8 vs 251.8 ± 152.7 P. value 0.01) respectively (Table 1)

Summary

Introduction

HIV is lentivirus (sub group of retrovirus) that causes HIV infection and acquires immunodeficiency syndrome (AIDS) [1] [2]. Background: The elevation of plasma D-dimer levels is fully described and associated with the increase of the mortality of patients with HIV. The present study was aimed to estimate and assess the plasma D-dimer levels in HIV patient.

Results

Conclusion