Estimating Whole-Brain Dynamics by Using Spectral Clustering

Abstract

SummaryThe estimation of time varying networks for functional magnetic resonance imaging data sets is of increasing importance and interest. We formulate the problem in a high dimensional time series framework and introduce a data-driven method, namely network change points detection, which detects change points in the network structure of a multivariate time series, with each component of the time series represented by a node in the network. Network change points detection is applied to various simulated data and a resting state functional magnetic resonance imaging data set. This new methodology also allows us to identify common functional states within and across subjects. Finally, network change points detection promises to offer a deep insight into the large-scale characterizations and dynamics of the brain.