Estimating the Correlation between Autoimmune Thyroid Disorders and Chronic Spontaneous Urticaria: A Study Protocol

Abstract

Background: Chronic spontaneous urticaria is thought to occur due to the patient's predilection to produce self-reactions. Urticaria contributes to loss of sleep, anxiety, depression, lack of motivation and social isolation, which may contribute to a substantial decrease in the patient's quality of life. Chronic spontaneous urticaria is unpredictable and can impair the patient's usual everyday activities. Autoimmune thyroid disorders are as a consequence of immune system dysregulation, that results in a thyroid invasion. A relationship between Chronic Spontaneous Urticaria and Autoimmune Thyroid Disorders is related to the duration and severity of the disease. Chronic Spontaneous Urticaria is associated with the presence of antithyroid antibodies. This study aims to analyze the changes in Patients detected with T3, T4, TSH and anti-TPO of chronic spontaneous urticaria, in contrast to normal healthy individuals and patients with other skin diseases which do not have abnormal thyroid etiopathogenesis.
 Materials and Methods: This will be a Case Control study conducted at Department of Dermatology, AVBRH, Sawangi, Wardha. Patients with chronic spontaneous urticaria will be subjected to a thorough clinical review and will be scored based on urticaria severity scoring. To test for autoimmune thyroid disease, the levels of T3, T4, TSH and anti-TPO antibodies will be traced. Data will be collected and analysed with appropriate statistical tests.
 Expected Results: Statistical correlation between chronic spontaneous urticaria and autoimmune thyroid disorders which can aid in the early detection and arrest of progression of autoimmune thyroid disorders in chronic spontaneous urticaria.
 Conclusion: Preventive steps toward patient management can be taken with this analysis in chronic spontaneous urticaria, in patients with deranged parameters for the T3, T4, TSH and ANTI – TPO.