Abstract
Background The Philippines is among the 39 countries aiming for malaria elimination. The major challenge is finding residual transmission foci in difficult to access villages of Southern Mindanao, Philippines. The sensitivity of microscopy to detect asymptomatic infections declines with decreasing malaria prevalence. The aim of this project is to use antibody markers of P. falciparum and P. vivax infection to locate residual transmission foci and to determine effects of control measures in Sarangani Province, the Philippines.
Highlights
The Philippines is among the 39 countries aiming for malaria elimination
Sera extracted blood spots were tested for presence of antibodies to P. falciparum and P. vivax apical membrane antigen 1 (AMA1) and merozoite surface protein 1 (MSP119) using indirect ELISA [1].The mixture model was used to define the cut off value for presence or absence of antibody to the antigen tested
The age-specific seroprevalence curves for Pf-AMA1 and Pf-MSP119 showed that the force of P. falciparum infection (l) per year in Sarangani Province was 0.005 and 0.03, respectively
Summary
The Philippines is among the 39 countries aiming for malaria elimination. The major challenge is finding residual transmission foci in difficult to access villages of Southern Mindanao, Philippines. The sensitivity of microscopy to detect asymptomatic infections declines with decreasing malaria prevalence. The aim of this project is to use antibody markers of P. falciparum and P. vivax infection to locate residual transmission foci and to determine effects of control measures in Sarangani Province, the Philippines
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