Abstract

To dynamically compare cystatin C estimated glomerular filtration rate (eGFRcys-c) and creatinine estimated glomerular filtration rate (eGFRScr) in acute kidney injury (AKI) patients in intensive care unit (ICU) to provide enlightenment for GFR estimation. Significant positive correlations existed between 538 paired value of cystatin C and creatinine. eGFRcys-c was significantly lower than eGFRScr. The values of eGFRcys-c and eGFRScr at 3 different timepoints were recorded for repeated measures analysis of variance. The results indicated that, with the progress of AKI, eGFRcys-c significantly decreased. eGFRScr had no significant decreases after a diagnosis of AKI. The time interval of eGFRcys-c up to the standard of RIFLE of AKI was significant shorter than eGFRScr. In conclusion, eGFRcys-c may reflect the change of GFR more sensitive and earlier than eGFRScr in ICU AIK patients. More in-depth studies are warranted. Key words: Acute kidney injury; Glomerular filtration rate

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