Estimating coupling strength between multivariate neural series with multivariate permutation conditional mutual information

Abstract

Recently, coupling between groups of neurons or different brain regions has been widely studied to provide insights into underlying mechanisms of brain functions. To comprehensively understand the effect of such coupling, it is necessary to accurately extract the coupling strength information among multivariate neural signals from the whole brain. This study proposed a new method named multivariate permutation conditional mutual information (MPCMI) to quantitatively estimate the coupling strength of multivariate neural signals (MNS). The performance of the MPCMI method was validated on the simulated MNS generated by multi-channel neural mass model (MNMM). The coupling strength feature of simulated MNS extracted by MPCMI showed better performance compared with standard methods, such as permutation conditional mutual information (PCMI), multivariate Granger causality (MVGC), and Granger causality analysis (GCA). Furthermore, the MPCMI was applied to estimate the coupling strengths of two-channel resting-state electroencephalographic (rsEEG) signals from different brain regions of 19 patients with amnestic mild cognitive impairment (aMCI) with type 2 diabetes mellitus (T2DM) and 20 normal control (NC) with T2DM in Alpha1 and Alpha2 frequency bands. Empirical results showed that the MPCMI could effectively extract the coupling strength features that were significantly different between the aMCI and the NC. Hence, the proposed MPCMI method could be an effective estimate of coupling strengths of MNS, and might be a viable biomarker for clinical applications.