Abstract
This study aimed to characterize energy expenditure patterns using the triaxial accelerometer and to identify the association of energy expenditure with clinical parameters in patients with systemic lupus erythematosus (SLE). Estimates of energy expenditures represented by total activity calorie (TA), physical activity calorie (PA), total activity calorie per body weight (TABW), and physical activity calorie per body weight (PABW) of 49 female SLE patients were assessed using the RT3 triaxial accelerometer (StayHealthy, Monrovia, CA) in a sevenday period. SLE patients in the highest body mass index (BMI) tertile showed significantly lower values of TABW compared to those in the lowest tertile, while SLE patients in the lowest TABW tertile showed significantly higher body weight, waist circumference, BMI, SLE disease activity index (SLEDAI), dosage of prednisone, and blood pressure. There was a high prevalence of metabolic syndrome and SLE patients with metabolic syndrome showed significantly lower TABW. In addition, both TABW and PABW significantly but negatively correlated with SLEDAI. In conclusion, the RT3 accelerometer is suitable for evaluating total and physical activity-related energy expenditure in patients with SLE. TABW measured by the triaxial accelerometer is inversely related with body weight status and disease activity in SLE patients. This suggests that estimates of energy expenditure by the tri-axial accelerometer may be applied in the management of SLE.
Highlights
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the activation of T and polyclonal B cells and by a wide variety of immunologic abnormalities [1]
Average estimates of energy expenditures measured by the RT3 accelerometer were 1730 ± 218 Kcal/day total activity calorie (TA), 284 ± 108 Kcal/day physical activity calorie (PA), 26 ± 3 Kcal/kg/day total activity calorie per body weight (TABW), and 4 ± 1 Kcal/kg/day PABW
SLE disease activity index (SLEDAI) significantly correlated with body weight (r = 0.434, p = 0.002) and body mass index (BMI) (r = 0.379, p = 0.007)
Summary
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the activation of T and polyclonal B cells and by a wide variety of immunologic abnormalities [1]. Previous studies demonstrate that SLE patients present with limitations in exercise capacity and reduced quality of life due to various clinical complaints [2]. The exercise intolerance of SLE patients is associated with a reduced aerobic capacity of peripheral muscles [3], such that SLE patients are less aerobically fit, with reduced exercise capacity, reduced muscle strength, more fatigue, and greater disability compared to sedentary controls [4]. There is strong evidence on the relationship between physical activity and the primary prevention of chronic health problems in women [5]. Estimates of energy expenditure provided a better indicator of physical activity. Methods to assess energy expenditure have strengths and limitations [6]
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