Abstract
BackgroundEstimated plasma volume status (ePVS) has been reported that associated with poor prognosis in heart failure patients. However, no researchinvestigated the association of ePVS and prognosis in patients with acute myocardial infarction (AMI). Therefore, we aimed to determine the association between ePVS and in-hospital mortality in AMI patients.Methods and resultsWe extracted AMI patients data from MIMIC-III database. A generalized additive model and logistic regression model were used to demonstrate the association between ePVS levels and in-hospital mortality in AMI patients. Kaplan–Meier survival analysis was used to pooled the in-hospital mortality between the various group. ROC curve analysis were used to assessed the discrimination of ePVS for predicting in-hospital mortality. 1534 eligible subjects (1004 males and 530 females) with an average age of 67.36 ± 0.36 years old were included in our study finally. 136 patients (73 males and 63 females) died in hospital, with the prevalence of in-hospital mortality was 8.9%. The result of the Kaplan–Meier analysis showed that the high-ePVS group (ePVS ≥ 5.28 mL/g) had significant lower survival possibility in-hospital admission compared with the low-ePVS group (ePVS < 5.28 mL/g). In the unadjusted model, high-level of ePVS was associated with higher OR (1.09; 95% CI 1.06–1.12; P < 0.001) compared with low-level of ePVS. After adjusted the vital signs data, laboratory data, and treatment, high-level of ePVS were also associated with increased OR of in-hospital mortality, 1.06 (95% CI 1.03–1.09; P < 0.001), 1.05 (95% CI 1.01–1.08; P = 0.009), 1.04 (95% CI 1.01–1.07; P = 0.023), respectively. The ROC curve indicated that ePVS has acceptable discrimination for predicting in-hospital mortality. The AUC value was found to be 0.667 (95% CI 0.653–0.681).ConclusionHigher ePVS values, calculated simply from Duarte’s formula (based on hemoglobin/hematocrit) was associated with poor prognosis in AMI patients. EPVS is a predictor for predicting in-hospital mortality of AMI, and could help refine risk stratification.
Highlights
Acute myocardial infarction (AMI) is the most severe coronary artery disease and the leading cause of mortality worldwide, which accounts for almost 1.8 million annual deaths in Europe [1], and the estimated annualChen et al BMC Cardiovasc Disord (2021) 21:530 incidences of new and recurrent MI events in America are 0.55 million and 0.2 million events, respectively [2]
EPVS is a predictor for predicting in-hospital mortality of acute myocardial infarction (AMI), and could help refine risk stratification
Kobayashi et al indicated that Estimated plasma volume status (ePVS) derived from Duarte formula was significantly associated with echocardiographic parameters of chronic heart failure (HF) patients [8]
Summary
Acute myocardial infarction (AMI) is the most severe coronary artery disease and the leading cause of mortality worldwide, which accounts for almost 1.8 million annual deaths in Europe [1], and the estimated annualChen et al BMC Cardiovasc Disord (2021) 21:530 incidences of new and recurrent MI events in America are 0.55 million and 0.2 million events, respectively [2]. Whether the association between plasma volume (PV) and in-hospital mortality in AMI patients remains unclear, and there is no relevant research report until now. Duarte et al proposed a simple formula based on hematocrit and hemoglobin to estimate the plasma volume status [6]. Kobayashi et al indicated that ePVS derived from Duarte formula was significantly associated with echocardiographic parameters of chronic HF patients [8]. Estimated plasma volume status (ePVS) has been reported that associated with poor prognosis in heart failure patients. No researchinvestigated the association of ePVS and prognosis in patients with acute myocardial infarction (AMI). We aimed to determine the association between ePVS and in-hospital mortality in AMI patients
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
