Abstract
BackgroundA genetic predisposition for certain tumour types has been proven for some dog breeds. Some studies have suggested that this may also be true for the Golden retriever breed. The present study aimed to examine a possible existence of a tumour (type) predisposition in the Dutch population of Golden retrievers by evaluating annual estimated incidence rates compared to incidence rates from previous publications. A second aim was to evaluate whether incidences of various tumours differed as related to the diagnostic method chosen, being either cytology or histology.ResultsTumours submitted to Utrecht University during the period 1998–2004 diagnosed either by means of cytology (n = 2,529) or histology (n = 2,124), were related to an average annual Dutch kennel club population of 29,304 Golden retrievers.Combining individual tumours from both the cytological and the histopathological data-set resulted in an annual estimated incidence rate of 2,242 for 100,000 dog-years at risk regarding tumour development in general.The most common cytological tumor diagnoses were ‘fat, possibly lipoma’ (35%), mast cell tumour (21%) and non-Hodgkin lymphoma (10%). The most commonly diagnosed tumours by histology were mast cell tumour (26%), soft tissue sarcomas (11%) and melanoma (8%). Both the cytological and histopathological data-sets, showed variation; in patient age distribution, age of onset and incidence of various tumours.ConclusionComparing our data with previous reports in non-breed-specified dog populations, the Golden retriever breed shows an increased risk for the development of tumours in general, as well as an increased risk for the development of specific tumour types, including the group of soft tissue sarcomas. Variations in age, location and incidence of various tumours were observed between the two data-sets, indicating a selection bias for diagnostic procedure.
Highlights
A genetic predisposition for certain tumour types has been proven for some dog breeds
Tumours diagnosed by cytology mostly originated from the mesenchym
Second most frequent were tumours that originated from hematopoietic origin
Summary
A genetic predisposition for certain tumour types has been proven for some dog breeds. The present study aimed to examine a possible existence of a tumour (type) predisposition in the Dutch population of Golden retrievers by evaluating annual estimated incidence rates compared to incidence rates from previous publications. Clear evidence exists for a breed-related predisposition to specific soft tissue sarcomas (STS) [24,25,26,27] The limitations of these studies are old age in the dogs, and the fact that many studies were hospital-based and of small size. There is need for larger studies that include examination of reports of diagnostic procedures to obtain more solid data on the relative tumour incidence. Such larger studies should enable better assessment of a possible predisposition for specific tumour types in breeds such as the Golden retriever. Regional variation in genetic population structure may appear [28]
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