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Abstract
OBJECTIVESRecurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea.METHODSWe conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1).RESULTSDuring 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis.CONCLUSIONSThe estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.
Highlights
The estimated incidence of juvenile-onset respiratory papillomatosis (RRP) in South Korea was similar to that reported in other countries
Recurrent respiratory papillomatosis (RRP) is a benign but potentially troublesome disease caused by human papillomavirus (HPV), which is characterized by the appearance of papillomatous lesions in the respiratory tract [1]
In this study, we found that juvenile-onset RRP is rare in South Korea, with an annual incidence rate of 0.30 per 100,000 person-year among aged ≤12 years
Summary
Recurrent respiratory papillomatosis (RRP) is a benign but potentially troublesome disease caused by human papillomavirus (HPV), which is characterized by the appearance of papillomatous lesions in the respiratory tract [1]. This study estimated the incidence and analyzed the demographic characteristics of Korean children t diagnosed with juvenile-onset RRP prior to the introduction of the HPV vaccination of prin program in South Korea. The NHIS claims database contains details on diagnoses, treatments and medical services, prescriptions, number of outpatient visits, length of hospitalization, cost of care, the medical institution, as well as the income level and place of residence of all insured [21]. Int The RRP cohort was followed up until December 31, 2015 Their use of medical pr services, such as the number of hospital visits and surgical treatments, was the of outcome of interest. The incidence rate was calculated as the total number of cases ahead divided by total person-year (i.e., mid-year population of children born between 2002 and 2014 [22] multiplied by the follow-up years). This study used secondary data contained no personal information, and the requirement for informed consent was waived by the institutional review board
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