Estimated glucose disposal rate in patients under 18 years of age with type 1 diabetes mellitus and overweight or obesity

Abstract

Abstract Objective To assess the estimated glucose disposal rate (eGDR), insulin dose, and lipoprotein profile in children with type 1 diabetes mellitus (T1DM) and overweight or obesity as compared to children with T1DM and normal weight. Methods A total of 115 patients (aged 5–16 years) with T1DM on intensive insulin therapy were recruited. The following parameters were measured: weight, height, body mass index, waist and hip circumference, insulin dose, eGDR, glycosylated hemoglobin, blood pressure, and lipoprotein profile. Results were stratified by sex and age. Results No significant differences were found in eGDR between children with normal weight, overweight, and obesity. However, obese children older than 11 years had lower eGDR values (9.3 ± 1.3 vs 10.1 ± 0.8 mg kg −1 min −1 ; p 2 /day (37.7 vs 36.1 vs 29.4 respectively; p p Conclusions Values of eGDR values were lower in obese children with T1DM older than 11 years, and this may therefore be considered a marker of insulin resistance. Insulin dose was higher in diabetic patients with overweight or obesity, especially in IU/m 2 /day. Obese children with T1DM had a lipoprotein profile of cardiovascular risk.