Estimated glomerular filtration rate for drug dose adjustment: Cockcroft and Gault or abbreviated MDRD equation?

Abstract

Objectives Evaluate if Cockcroft and Gault (CG) estimated glomerular filtration rate (eGFR) might be replaced by abbreviated MDRD eGFR for drug dose adjustment. Design and methods eGFR was determined in 140 hospitalized patients (median: 68 years, 65 kg) treated by nephrotoxic and/or renally cleared drugs. Results CG eGFR was 61 mL/min vs. 78 mL/min/1.73 m 2 for MDRD ( p < 0.0001). CG-MDRD difference ranged from − 93 to + 34 mL/min, influenced by patient age, weight, and gender ( p < 0.001). Conclusions CG eGFR cannot be easily replaced by abbreviated MDRD eGFR for drug dose adjustment.