Estimated glomerular filtration rate (eGFR) changes after obstructive sleep apnea (OSA) treatment by positive airway pressure: data from the European Sleep Apnea Database (ESADA)

Abstract

Decreased renal function is associated with OSA in the ESADA cohort (Marrone et al, J Sleep Res 2016). Aim of this study was to evaluate changes in eGFR (∆eGFR) after different modalities of positive pressure treatment. Data from 1,806 OSA patients who were treated by fixed (n=1,177, CPAP) or automatic (n=485, APAP) continuous positive airway pressure were analyzed and compared with data from a group of untreated patients (n=144). Median follow-up was 541 days (IQR 220-1255). Median baseline eGFR was 91.42 ml/min/1.73m2. During follow-up, eGFR decreased particularly in the patients with eGFR below the median at baseline (p Multiple regression analysis identified advanced age, female gender, cardiac failure, higher baseline eGFR and longer follow-up duration as negatively, and CPAP as positively affecting eGFR (β=3.420 [1.564/5.276], p