Esters of fluorine-containing ?-keto acids in the reaction with amines

Abstract

1. Methyl esters of fluorine-containing α-ketoacids with methylamine, regardless of the nature of the solvent, give addition products at the α-keto group and products of aminolysis of the ester group. 2. Esters of fluorine-containing α-ketoacids react regiospecifically with diethylamine at the ester group, giving N,N-diethylamides of α-hydroxy-α-methoxyfluorocarboxylic acids in aprotic media and diethylammonium salts of fluorine-containing α,α-dihydroxyfluorocarboxylic acids in proton donor media; upon heating, the diethylammonium salts eliminate water with the formation of diethylamides.