Abstract
Changes in the car☐ylic acid esterase activities from crude myelin fractions and subfractions of myelin were followed during the development of guinea-pig brains. Animals from 15 days to 1 year of age were used. A rapid decrease of activity towards α-naphthyl acetate and β-naphthyl acetate was observed especially in the first myelin-like (M 2) fraction. This decrease was somewhat more moderate in the second myelin-like (M 2) fraction. On the other hand, α-naphthyl propionate and β-naphthyl laurate activities were quite different. Only minor changes could be demonstrated in the M 2 fraction during myelination, and there were no significant alterations in the second myelin-like fraction during the same period. These results fit with earlier findings concerning changes in short- and long-chain fatty acid patterns of myelin during development.
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