Establishment of quality standards for syrup from viburnum fruit meal

Abstract

An adjusted dosage form has been developed in the form of a syrup using low-waste technology — from the meal of the fruits of Viburnum viburnum. Viburnum fruit meal contains higher fatty acids, triterpenoids, phytosterols, and carotenoids. Medicines of plant origin have a number of undeniable advantages compared to synthetic ones, since their composition ensures safety and better tolerability due to the variety of biologically active substances (BAS) of plants, they can have a complex effect on the body, and they can be used for a long time. However, the main issue is that, despite their high bioavailability and cost-effectiveness, herbal medicines are complex to design and require the development of a number of technological solutions. Equally important are the issues of establishing quality standards — standardization of the developed dosage form. The syrup was prepared from simple sugar syrup with the addition of dry extract from viburnum fruit meal. Purpose of work. Development and establishment of quality standards for the developed dosage form — syrup from viburnum fruit meal. Materials and methods. High performance liquid chromatography (HPLC) method. Let us use it to establish standards in quantitative terms for chlorogenic acid. Permanganatometry. This technique was used to determine the quantitative content of the amount of tannins in terms of gallic acid. Results. It was established that the content of chlorogenic acid in the developed syrup is 0.214 ± 0.006 %, the content of tannins in terms of gallic acid is 0.494 ± 0.014 %. Indicators acidity (pH) — 3–5, density — 1,360 to 1,420 g/cm3, microbiological purity — category 3 B. Conclusion. The result of the research was the establishment of the main indicators of syrup quality, namely the quantitative content of the main biologically active substances — chlorogenic acid and tannins in terms of gallic acid. In addition, such indicators as acidity (pH), density, and microbiological purity were determined.