Abstract
In order to enhance promising properties of polyethertherketone (PEEK) for biomedical application, we evaluate two different strategies for the provision of PEEK with a drug delivery system at the example of the model drug chlorhexidine diacetate. On one hand we discuss the deposition of a biodegradable polymeric drug-release coating, based on well-established poly(L-lactide) (PLLA), on PEEK and on the other hand the modification of PEEK via sulfonation and its subsequent drug loading. Results are compared to pure PLLA-associated drug delivery systems and limits and perspectives are shown.
Highlights
Polyetheretherketone (PEEK) has been originally created in 1978 by a group of British researchers [1]
In order to enhance promising properties of polyethertherketone (PEEK) for biomedical application, we evaluate two different strategies for the provision of PEEK with a drug delivery system at the example of the model drug chlorhexidine diacetate
The first approach is the deposition of a polymer coating with drug incorporation on the surface of PEEK and the second approach is the sulfonation of PEEK in order to modify its solubility properties and thereby allow for drug incorporation within solution and subsequent film preparation via solvent casting
Summary
Polyetheretherketone (PEEK) has been originally created in 1978 by a group of British researchers [1]. By the late 1990s, PEEK entered the medical sector and became a promising polymer alternative to metal implant components, especially in orthopedic and traumatic applications and in dentistry. The benefit of using PEEK instead of metal components is the amazing biomechanical property. While traditionally used dental and orthopedic implant materials (such as titanium) have a relatively high Young’s modulus of 116 GPa compared to bone [3], the Young’s modulus of PEEK is about 3.6 GPa, which can be enhanced to 18 GPa by means of fibre reinforcement [4]. As cortical bone evidences a comparable elastic modulus [5] [6], stress shielding is supposed to be lower for PEEK compared to titanium.
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