Abstract

The establishment of embryonic stem cells (ESCs) with one set of maternal genome will be able to provide the valuable cell source for the genetic analysis of female genome, the production of genetically modified animals, and the regenerative medicine. However, available information about these ESCs is very limited. The aim of this study was to establish gynogenetic haploid ES cells (GHESCs) with maternal haploid genome in mice. In addition, we performed the generation of cloned oocytes by using nuclear transfer with GHESCs.

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