Abstract
Objective To establish a orthopedic high-quality biobank in accordance with international standards, which includes clinical information and biospecimen, and to provide a resource platform for early diagnosis and early warning systems of orthopaedic degenerative disease. Methods First the criteria of inclusion and exclusion were established. Second, the organization, informed consent procedure, standard operating procedures and biological information platform were set up. According to the standard operating procedures, biological samples were collected from inpatients who suffered from orthopaedic degenerative diseases and healthy volunteers. Results The biological sample library for orthopaedic degenerative disease, including organizational andmanaging system, standardized process, infrastructure, information system and entitative specimen library were established. From January 2010 to December 2014, clinical data of 6 819 patients and 36 403 samples of blood and tissues have been collected. 29.33% (2 000/6 819) of the samples from Biobank were used for research projects. Conclusion Establishment of international standardized and high-quality biobank for orthopaedic degenerative disease is an important guarantee for improving the level of the orthopaedic basic research and clinical medicine, which may help to realize the precision medicine. Key words: Hospitals, osteopathic; Intervertebral disc degeneration; Osteoarthritis
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