Abstract
Objective To investigate the probability for establishment of acidic reflux esophagitis (RE) in rats. Methods Eighty Wistar rats were randomly divided into four groups with 20 rats in each group: study groups A and B, and control groups C and D. RE was induced by ligation of the pylorus ring and the forestomach. The rats in control groups underwent repair of gastrostomy, and those in groups A and C were sacrificed at the 7th day after the procedure, and those in groups B and D at the 14th day after the procedure. The pH values of lower esophageal mucosa (pHLEM) were detected during the procedure and sacrifice time. The survival rate of each group was recorded and the histologic changes of esophagus were examined. Results Four rats died during the procedures. The survival rate in groups A, B, C and D was 68.4% (13/19), 47.4% (9/19), 83.3% (15/18) and 95. 0% (19/20), respectively. There was statistically significant difference in the survival rate between groups B and D (P 0.05). Conclusion It is feasible to establish a successful rat model of acidic RE by ligation of the pylorus ring and the forestomach. Key words: Esophagitis; Peptic; Model, animal
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