Abstract
Objective The aim of this study was to develop a porcine model of left single lung auto-transplantation. Methods Eighteen 50-kg male domestic pigs underwent left pneumonectomy and lobar lung auto-transplantation (left lower lobe). Each animal was allocated to a perfusion protocol during surgery: group I, cold saline (n = 6); group II, cold heparin (n = 6); and group III, cold Euro-Collins (n = 6). We measured changes of partial pressure of oxygen in pulmonary vein blood (PvO 2), partial pressure of carbon dioxide in pulmonary vein blood (PvCO 2), lung compliance, and mean pulmonary artery pressure. Results The postoperative survival rate was 100%. PvO 2, PvCO 2, mean pulmonary artery pressure, and lung compliance of the left lower lobe showed a significant difference between the saline and the heparin groups or the Euro-Collins group ( P < .05), whereas there was no significant difference between the heparin and the Euro-Collins groups. Conclusion Compared with other species, humans and pigs show remarkable anatomical and physiological similarity. It is useful experimental animal model to evaluate pulmonary function and grafting protocols following lobar lung transplantation.
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