Establishment of a new concept of the immune system, disclosure of causes, and development of the therapeutic system of immune diseases

Abstract

Using hybrid-type artificial organs made of bioceramics, synthetic research has been carried out to investigate the immune system of mammals. It has been shown that the causes of human systemic immune diseases are brought about by energy influencing organisms, and a hindrance of the energy metabolism of mitochondria by intracellular parasites. From this discovery, a new therapeutic system against human-specific intractable diseases has been developed and a new concept of immunology established. From the results of these synthetic experiments, self and non-self immunology can be completely exposed as non-scientific theories like teleological adult-fairy tales, akin to the Darwinist theory of evolution. It is shown that the driving force of evolution is a movement against the force of gravity and the mechanisms of evolution of the vertebrates is verified according to the Use and Disuse theory of Lamarck by means of experimental evolutionary studies using bioceramics. Lamarck's Theory is shown to be based on phenomena of metaplasia in molecular biology. The development of MHC (major histocompatibility complex), i.e. HLA or human leukocyte antigen, arises through the gravity-corresponding movement of the vertebrates during the second revolution in evolution, i.e. landing. The major function of MHC is to detect abnormal cell membranes, such as aged cells, neoplastic cells, and intracellularly infected cells by viruses, bacteria, and protozoa that destroy and remodel cells, and the regeneration and renewal as well as de novo synthesis of cells. The tissue immune system and the mechanisms of immunotolerance from the viewpoint of Haeckel's Biogenic Law have also been studied using chondrichthyes (sharks) as archetype vertebrates. It is well known that these archetype vertebrates have the MHC gene. From this research it has been shown that the gene expression of MHC, or HLA, is triggered during acquisition of bone marrow hemopoiesis and development of sympathetic nerves concomitant with the pyramidal tract of cerebral motor nerves as well as the emergence of the homothermal system. Thus it has been shown that the immune system is essentially cellular renewal i.e. a remodeling system; this is concomitant with the energy metabolism of mitochondria by means of the cellular digestion system of leukocytes, namely, the MHC of leukocyte membranes (HLA) that detectg deteriorated membranes of infected cells as well as tumor cells. This cellular digestion system in mammals depends upon the homothermal system as well as the energy metabolism of mitochondria. The therapeutic system of systemic immune diseases has developed to control the energy influencing the human body and to prevent or cure intracellular infections with non-pathogenic enteric parasitic bacteria.