Abstract
A canine malignant melanoma cell line (CMMe) was established from tiremetastatic foci of a malignant oral melanoma. The cell line has been subcultured 130passages during 3.5 years, and has continued to produce melanin pigment in monolayercultures. The cell line generally consists of triangular and fusiform cells with numerousmelanin grannies. Melanosomes in various stages of maturation were detected in most ofthe cultured cells by electron microscopy. The population doubling time of the cell linewas 68 hours at the 25th passage, and chromosome number showed wide distribution from44 to 106 with a mode of 52. I].eterotransp1antation of cultured cells into the nude miceproduced black nodules and histological appearance of the nodule was similar to that ofthe original tumor.
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Schedule a callMore From: Nihon juigaku zasshi. The Japanese journal of veterinary science
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