Abstract
Objective To establish a experimental rabbit model of antigen-induced arthritis and discuss its MRI manifestations.Methods Unilateral arthritis was induced by means of intraartieular injection of ovalbumin in 7 knees of 7 rabbits that had been presensitized to the same antigen.All knees were imaged at 5,15 days after onset of arthritis.MR findings were correlated with histopathologic findings.Results 6 knees with intraarticular injection of antigen suspension developed unilateral arthritis.Precontrast image showed thickening of joint effusion and synovium.The Joint effusion or synovium showed hypo-or/so-intensity on T1-weighted spin-echo,while inhomogeneouos hyper-intensity on T2-weighted spin-echo.It could be difficult to differentiated from one another.Postcontrast image (after Gd-DTPA administration) showed marked enhancement,whereas joint effusion did not.Synovium increasing was more distinctive on 15 day than on 5 day after intraarticular injection.The results of histopathologic evaluation confirmed the MR findings,with presence of marked to extensive synovial hyperplasia in all 6 arthritic knees of the antigen-injected group.Cellular infiltrates containing monocytes,lymphocytes,and macrophages were noted within the hyperplastic synovium of the arthritic knees.Conclusions The pathological process development and MRI manifestations in the rabbit model of antigen-induced arthritis is similar to that in human beings,so that it is a good lab model of rheumatoid arthritis. Key words: Experimental; Rabbit model of antigen-induced arthritis; MRI
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