Abstract
Dysphagia induces aspiration and causes aspiration pneumonia. There is no treatment for dysphagia fundamentally. Haloperidol reportedly induces dysphagia. In the present study, we established a haloperidol-induced dysphagia model in guinea pigs, and evaluated the effects of ginger, kikyoto, and a mixture of ginger and kikyoto on swallowing. Swallowing ability was evaluated using behavioral tests, computed tomography (CT), and videofluoroscopic examination of swallowing. To investigate the effect of ginger and kikyoto on swallowing, ginger, kikyoto, or a mixture of ginger and kikyoto was administered orally to guinea pigs with haloperidol-induced dysphagia. Effects of these compounds were evaluated with behavioral tests. Chronic administration of haloperidol reduced the number of swallows, as evaluated by the behavioral test and videofluoroscopic examination of swallowing. In our model, these compounds improved swallowing dysfunction. Our results suggest that this model might be useful in revealing the pathogenesis of dysphagia and evaluating compounds that might improve swallowing.
Highlights
Dysphagia is the impairment of swallowing abilities, and often causes aspiration pneumonia [1]-[3]
We investigated the swallowing ability of the guinea pigs with videofluoroscopic examination
On day 15 of the haloperidol injection, the number of swallows induced by oral administration of 700 μl contrast medium was measured for 1 min using videofluoroscopy (n = 9)
Summary
Dysphagia is the impairment of swallowing abilities, and often causes aspiration pneumonia [1]-[3]. How to cite this paper: Mizoguchi, T., Ishisaka, M., Kobatake, Y., Kamishina, H., Nishioka, Y., Kirimoto, T., Shimazawa, M. and Hara, H. (2016) Establishment and Effects of Ginger and Kikyoto of a Haloperidol-Induced Dysphagia Model in Guinea Pigs. Several compounds were suggested to improve dysphagia [4]-[6]; no available medicine treats dysphagia fundamentally. Few studies report about animal models of dysphagia [7]. Animal models of swallowing dysfunction are required to develop novel therapeutic drugs for the treatment of dysphagia
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