Abstract
ylococcus aureus (SA) colonization or exit site infection. Methods: We enrolled 89 PD patients in 1 year study period. We first decolonized SA nasal carrier with mupirocin and chlorhexidine bathing. After stratification by initial SA carrier status, patients were randomly assigned to receive daily chlorhexidine care (intervention group, n Z 50) or normal saline (control group, n Z 39) at exit site. Outcome measurements included time free of SA colonization or time to exit site infection. Results: The underlying disease, dialysis duration, and baseline exit site scoring were similar in intervention and control group. SA colonization rate at the 6th /12th month were significant lower in intervention group than control group (5.0% vs. 22.9%; p Z 0.023 in the 6th month) (8.6% vs. 28.1%; p Z 0.037 in the 12th month). MRSA colonization rate at 12th month were significant lower in intervention group than control group (0% vs. 12.5%; p Z 0.047). Exit site scoring was worse in control group than intervention group in the 6th month (0.66 VS. 0.12, P Z 0.008) but was similar in the 12th month (0.42 vs. 0.45, p Z0.88). Genotyping of MRSA isolates showed ST (sequence type) 59 was the most predominant clone.
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