Abstract
Graft-versus-host disease (GvHD) of the skin is a severe allo-immune reaction and complication following allogeneic stem cell transplantation. Over the past years, intensive pre-clinical research has led to an improved understanding of the pathophysiology of acute and to a lesser extend chronic GvHD. This has translated into the approval of several new agents for the treatment of both forms of GvHD. This review summarizes the most recent advances in underlying pathomechanisms, clinical trials and newly approved agents for GvHD, with a special focus on skin involvement.
Highlights
Graft-versus-host disease (GvHD) remains a frequent complication following allogeneic stem cell transplantation (HSCT)
This review summarizes the most recent advances in underlying pathomechanisms, clinical trials and newly approved agents for GvHD, with a special focus on skin involvement
For the treatment of skin-predominant forms of acute GvHD, extracorporeal photopheresis (ECP) has been proven to be effective while reducing the cumulative amount of systemic steroids required in clinical trials [12] and real world settings [21]
Summary
Graft-versus-host disease (GvHD) remains a frequent complication following allogeneic stem cell transplantation (HSCT). This review summarizes the most recent advances in underlying pathomechanisms, clinical trials and newly approved agents for GvHD, with a special focus on skin involvement. For locally restricted forms of grade I acute skin GvHD, the initial treatment approach will consist of a topical steroid [17].
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