Abstract
Purpose: Kashin-Beck disease (KBD) is an endemic Osteoarthritis (OA) and usually develops in adolescents due to necrosis of cartilage. Besides, it leads to cartilage internalization disorder and osteoarthrosis. Short stature, joint pain, deformity, and even disability are the major clinical symptoms of KBD. Therefore, KBD severely affects the health of patients and reduces their quality of life. KBD is common in remote western China. Exploring the etiology and pathogenesis of KBD is still important for guiding the implementation of national decision-making, especially for endemic disease control.
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