Abstract
Potential involvement of T-helper (Th) 2-type responses in experimental murine models for inflammatory bowel diseases (IBDs) were investigated. Trinitrobenzene sulfonic acid (TNBS)-induced colitis was assessed in the Thl- or Th2-cytokine dominant condition using cytokine gene knockout mice and anti-cytokine monoclonal antibodies. Thl-type cytokine-dominant mice developed acute, focal, and transmural lesions. In contrast, Th2-type responses played a significant role in the diffuse atrophie changes in crypts and mucosal layer and in perpetuating disease. These findings will contribute to future immunological interventions in IBD.
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