Abstract
Backgrounds&aims: Tumour necrosis factor (TNF)-α triggers cell survival and apoptosis in hepatocytes. The cell survival pathway depends on post-translational modifications (PTM) leading to activation of NFκB. An essential PTM is ubiquitination that regulates NFκB activation at different steps. One important ubiquitination step depends on the linear ubiquitin chain assembly complex (LUBAC) that is responsible for ubiquitination of IKKγ (NEMO). As recently shown, LUBAC consists of HOIP, HOIL–1L and Sharpin. We analysed TNFα dependent NFκB activation in Sharpin-deficient primary hepatocytes (PH).
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