Abstract
Two different samples of the essential oil resin harvested from two trees of Protium heptaphyllum, growing in the Brazilian southeast seashores, were obtained by hydrodistillation and analyzed by GC and GC-MS. Monoterpenes were highly predominant in both compositions of the oils. The fresher sample, harvested from the tree A, showed the predominance of myrcene (35 %), α-pinene (27 %) followed by sabinene (11 %) and β-caryophyllene (7.2 %). Terpinolene (28 %) and p-cymene (16 %) were the largest components in the trunk resin tapped by mechanical hurt-induction from the tree B. Both samples were assayed in vitro for their ability to inhibit the growth of four different of neoplasic cell. The best results were obtained from the terpinolene/p-cymene chemotype, where inhibition of 67 %, 63 % and 59 % of mouse plasmocytoma (SP2/0), neuroblastome (Neuro-2A) and monocytic cell (J774) lineages were achieved, respectively. The growth of normal cell lineage MK2 (monkey kidney epitelial cells) increased about 50 % under treatment with the oils. The effects observed on neoplasic lineages were correlated to the presence of these monoterpenes.
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