Abstract
Background: The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance. Terrestrial plants could provide new leads to antibacterial, antifungal, or antiprotozoal activity. Methods: The essential oil (EO) of Piper aduncum L. (Piperaceae) from Cuba was analyzed by gas chromatography—mass spectrometry (GC-MS). A cluster analysis of P. aduncum EO compositions reported in the literature was carried out. The EO was screened against a panel of microorganisms (bacteria, fungi, parasitic protozoa) as well as for cytotoxicity against human cells. In addition, a review of scientific literature and a bibliometric study was also conducted. Results: A total of 90 compounds were identified in the EO, of which camphor (17.1%), viridiflorol (14.5%), and piperitone (23.7%) were the main components. The cluster analysis revealed at least nine different chemotypes. The EO did not show notable activity against bacteria or fungi, but was active against parasitic protozoa. Conclusions: The results from this study indicate P. aduncum from Cuba is a unique chemotype, support the importance of P. aduncum EOs as medicines, and demonstrate the promise of Cuban P. aduncum EO as a chemotherapeutic agent against parasitic protozoal infections.
Highlights
The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance
Parasitic protozoal infections cause much human morbidity and mortality. The prevalence of these diseases is higher in the tropics, where a significant number of deaths is attributed to malaria, leishmaniasis, African and American trypanosomiasis [36]—protozoal parasites that are included in this study
The results of this study support the importance of the essential oil (EO) from P. aduncum, in particular in regard to antiparasitic activity
Summary
The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance In this context, the search for new antimicrobial compounds from terrestrial plants could provide new leads to antibacterial, antifungal, or antiprotozoal activity. (Figure 1) have been widely studied, including antiprotozoal [4,5], anthelminthic and insecticidal [8,9] activities. Considering these previously antioxidant [7],[6], andantioxidant insecticidal[7],. A summary of relevant aspect in the cited scientific literatureaspect of EOin from cited scientific literature of from aduncum was reviewed and a bibliometric study was .
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