Abstract
SummaryPlasma protein bound iodine (PBI) of female rats fed an essential fatty acid (EFA) deficient diet for 15 weeks was higher than that of controls receiving dietary EFA, even though weight of the thyroid gland was less in deficient rats. After refeeding EFA to the deficient rats either as soybean oil or the colony stock diet for 3 weeks, the PBI concentration was decreased to the control values and the weights of the thyroid gland increased. Thiouracil added to the EFA-deficient diet lowered the PBI concentration in plasma and increased the weight of the thyroid gland. These data suggest that the increase in plasma PBI in EFA-deficiency is not dependent on TSH but the control mechanism that regulates the secretion of thyroidal iodine is dependent on essential fatty acids
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