ESR Position Paper on Imaging Biobanks.

European Society Of Radiology (Esr)

doi:10.1007/s13244-015-0409-x

Abstract

In March 2014 the European Society of Radiology (ESR) established a dedicated working group (ESR WG on Imaging Biobanks) aimed at monitoring the existing imaging biobanks in Europe, promoting the federation of imaging biobanks and communication of their findings in a white paper. The WG provided the following statements: (1) Imaging biobanks can be defined as “organised databases of medical images and associated imaging biomarkers (radiology and beyond) shared among multiple researchers, and linked to other biorepositories”. (2) The immediate purpose of imaging biobanks should be to allow the generation of imaging biomarkers for use in research studies and to support biological validation of existing and novel imaging biomarkers. (3) A long-term scope of imaging biobanks should be the creation of a network/federation of such repositories integrated with the already-existing biobanking network. The aim of the WG was to investigate the existence, consistency, geographical distribution and type of imaging biobanks in Europe. A survey among ESR members resulted in the identification of 27 imaging biobanks, mostly disease-oriented and designed for research and clinical reference. In 80 % access to imaging biobanks is restricted.Key points• Imaging biobanks are “shared databases of imaging biomarkers, linked to biorepositories”.• Exploitation of traditional and imaging biobanks is meaningful for “personalised medicine”.• A European imaging biobank network would significantly boost research in the imaging domain.

Highlights

Biobanks are repositories for the storage and retrieval of biological samples of a large number of subjects
Medical imaging biobanks are virtual biobanks recently emerging for advancing the study of rare, cardiovascular, oncologic and neurological diseases, the identification of early biomarkers and surrogates, and the development of population studies
These biobanks will evaluate the impact of new quantitative biomarkers in early disease diagnosis, disease phenotyping, disease grading, targeting therapies and evaluation of disease response to treatment

Summary

Introduction

Biobanks are repositories for the storage and retrieval of biological samples of a large number of subjects. A major goal of biobanks is the organised collection of biological material and associated information to spread access among scientists requiring this information [1]. The first biobank project, established in 1948, collecting blood samples and data, was the Framingham Heart Study (FHS), funded by the National Institute of Health-National Heart, Lung, and Blood Institute (NIH-NHLBI) [2]. Until recently, imaging data coming from sources such as magnetic resonance imaging (MRI) or computed tomography (CT) were not included in such biobanks. Over the past 3– 4 years, projects have been launched that plan to acquire large repositories of image data, including the UK Biobank and the German National Cohort [4,5,6]

Objectives

Findings

Conclusion