Esophago-Gastric Junction Carcinoma: State of the Art and Ongoing Trials in a Multimodal Approach

Abstract

Clinical management of Esophago-Gastric Junction (EGJ) carcinoma represents a challenge for gastrointestinal multidisciplinary tumor boards because of the opportunity of multimodal and combined treatments. The evolution of the guidelines, also in view of the classifications that have progressively helped to discriminate the various disease subsets and considering the evidence from clinical trials, can be very complex. The aim of this study is to report the main evidence on which the current guidelines are based, with a special focus on the grey areas that still exist and on ongoing studies that may provide further useful elements for the clinical management of this type of patient.