Abstract
Background: The development of esophageal stricture during treatment with high dose chemotherapeutic agents is well known and documented in the literature. With the introduction of proton pumps inhibitors (PPI), the gastroesophageal reflux disease (GERD) induced stricture has shown significant improvement. The aim of this report is to remind of the fact that the chemotherapy induced strictures show poor response and their treatment is still a challenge. Case presentation: Here, we reported a boy with Down syndrome and congenital heart disease who developed acute lymphoblastic leukemia and subsequent esophageal stricture during treatment with a PPI. Conclusion: It is important to be aware of this potential complication of gastroesophageal reflux or antineoplastic treatment, even in cases thought to be adequately treated with a proton pump inhibitor, and that the start of PPI’s is also the start of an evaluation of the use of this medication.
Highlights
IntroductionProton pump inhibitors (PPIs) are widely used to treat esophagitis in patients with gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD) to prevent complications such as esophageal stricture and bleeding [1] [2]
Proton pump inhibitors (PPIs) are widely used to treat esophagitis in patients with gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD) to prevent complications such as esophageal stricture and bleeding [1] [2].The development of esophageal stricture during treatment with high dose chemotherapeutic agents is wellHow to cite this paper: Arnbjörnsson, E. and Backman, T. (2015) Esophageal Strictures during Treatment with a Proton Pump Inhibitor
Esophageal stricture rarely occurs since the introduction of PPI therapy, there are some known risk factors for failure of PPI therapy including trisomy 21, chemotherapy, and gastrostomy
Summary
Proton pump inhibitors (PPIs) are widely used to treat esophagitis in patients with gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD) to prevent complications such as esophageal stricture and bleeding [1] [2]. (2015) Esophageal Strictures during Treatment with a Proton Pump Inhibitor. Backman known and documented in the literature. With the introduction of proton pumps inhibitors (PPI), the gastroesophageal reflux disease (GERD) induced stricture has shown significant improvement but the chemotherapy induced strictures show poor response and its treatment is still a challenge. We reported a boy with Down syndrome and congenital heart disease who developed acute lymphoblastic leukemia (ALL) and an esophageal stricture due to GER or antineoplastic treatment while receiving treatment with a PPI (omeprazole). We are not aware of any similar reports in the literature
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