Esophageal mucosal transcriptional alterations persist in eosinophilic esophagitis patients during remission

Abstract

Eosinophilic esophagitis (EoE) is a chronic disorder and patients typically relapse if they discontinue diet or medical therapy after obtaining remission. The molecular phenotype of EoE mucosa during remission is not well understood. Prior studies have shown basal cell hyperplasia and dilated intracellular spaces can persist during remission which suggests there may be persistent mucosal anomalies even if eosinophilic infiltrates are not present. Here, we investigate altered gene expression in the mucosa of EoE patients following treatment.