Abstract
BackgroundPrimary lung cancer is one of the most frequently diagnosed cancers. The common metastatic sites are the liver, bones, brain, adrenal glands and central nervous system. However, gastrointestinal metastases, particularly esophageal metastases, from lung cancer are rare. There are no cases of esophageal metastases from lung cancer which refer to its particular treatment.Case presentationWe report a case of esophageal metastases from lung cancer. The patient was a 55-year-old Han Chinese man who first attended our hospital due to dry cough and was diagnosed with late-stage lung cancer. Three months later, the patient complained of dysphagia. Endoscopic ultrasonography (EUS) and pathological examination of the biopsy specimen was performed to confirm the lesion was metastases from lung cancer. Thyroid transcription factor 1 (TTF-1), cytokeratin 7 (CK-7) and napsin A were positive by immunohistochemistry examination. These results reconfirmed the diagnosis of esophageal metastases from lung cancer.ConclusionsEsophageal metastasis from lung cancer is very rare. It may be alleviated with personalized chemotherapy. In addition, molecular targeted therapy for patients with epidermal growth factor receptor (EGFR) mutations may be reasonable.
Highlights
Primary lung cancer is one of the most frequently diagnosed cancers
We report a case of primary lung cancer metastasized to the esophagus and discuss diagnostic and
We learned by telephone follow-up that the patient died in January 2017. This case reported a patient who was diagnosed with primary lung cancer with multiple metastases at the first visit, and the tumor metastasized to the esophagus during treatment
Summary
Approximately 50% of patients present with metastases. Case presentation A 55-year-old Han Chinese man with a long-term history (30 years) of heavy smoking was referred to our hospital in March 2015 due to dry cough. His past medical history and family history were unremarkable. A computed tomography (CT) scan of the chest showed a 48 × 42 mm tumor in the left lower lobe (Fig. 2a). A positron emission tomography (PET)-CT scan revealed multiple metastases in the left lower lung, bilateral supraclavicular fossa, hilus pulmonis, mediastinal lymph nodes and bone (Fig. 2d). The patient underwent CT-guided biopsy of the lung lesion.
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