Abstract
TRUE esophagel leukoplakia has not been convincingly recognized during endoscopy as a clinical entity. Glycogenic acanthosis, which grossly resembles leukoplakia, has been frequently encountered at endoscopy and autopsy.1,2 We report a case of true esophageal leukoplakia due to hyperkeratosis without glycogenic acanthosis. To date this apparently benign condition has not been reported. Report of a Case Heartburn with regurgitation after meals developed in a 43-year-old cigarette smoker in 1973. Past medical and family history for gastrointestinal disease was unrevealing. The results of a physical examination were entirely unremarkable, including absence of oral or anal leukoplakia or keratosis palmaris et plantaris (tylosis). An initial upper gastrointestinal series showed slight narrowing of the distal esophageal lumen. At esophagoscopy, a 3-cm, sliding-type hiatal hernia with slight narrowing of the distal esophagus was observed in addition to free reflux of gastric contents into the lower esophagus. The esophageal mucosa appeared normal. However, on close
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